Synergistic anti-nociceptive effect of l-NG-nitro arginine methyl ester (l-NAME) and flurbiprofen in the mouse
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چکیده
منابع مشابه
NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.
Analogues of L-arginine with modifications at the terminal guanidino nitrogen and/or the carboxyl terminus of the molecule have been widely used for their ability to inhibit the production of nitric oxide and are thought to be competitive antagonists of nitric oxide synthase. The present studies were designed to test the possibility that these agents are also muscarinic receptor antagonists. Ac...
متن کاملEffect of inhaled NG-nitro-L-arginine methyl ester on Candida-induced acute lung injury.
STUDY OBJECTIVES Nitric oxide (NO) and peroxynitrite play a crucial role in acute lung injury (ALI). Whether NO synthase (NOS) inhibition is beneficial in the treatment of lung injury remains controversial. The objective of this study was to test the hypothesis that local inhibition of NOS in the lung reduces lung injury. DESIGN We developed a model of Candida-induced ALI in the mouse by IV i...
متن کاملEffects of NG-nitro-L-arginine methyl ester on renal function and blood pressure.
The dose-dependent effects of intravenous infusions of nitric oxide (NO) synthesis inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 0.1, 1, 10, and 50 micrograms.kg-1.min-1), were studied in anesthetized rats to determine whether the inhibitory actions of L-NAME are manifested primarily in alterations of renal function or whether they are the consequences of the increase in systemic blood p...
متن کاملSympathetic baroreceptor responses after chronic NG-nitro-L-arginine methyl ester treatment in conscious rats.
Blood pressure elevations after nitric oxide inhibition may result in part from increased sympathetic tone. In this study arterial baroreceptor reflex control of heart rate, renal sympathetic nerve activity (RSNA), and adrenal sympathetic nerve activity (ASNA) were compared in rats given normal tap water or a 3.7 nmol/L (10 mg%) solution of NG-nitro-L-arginine methyl ester (L-NAME) for 1 or 5 w...
متن کاملChronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy.
Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration induces cardiac hypertrophy in rodent models. Our aims is to determine the role of c-kit expression in L-NAME induced cardiac hypertrophy. 12-20 week old C57BL/6J mice (5 per group) were administered L-NAME (0.325mg/ml) in the drinking water. Hearts were excised at 1-day, 2-days, 5-days, 2-weeks or 6-weeks; or controls which recei...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1992
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1992.tb14362.x