Synergistic analgesic effects of intrathecal midazolam and NMDA or AMPA receptor antagonists in rats
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چکیده
منابع مشابه
Analgesic interaction between intrathecal midazolam and glutamate receptor antagonists on thermal-induced pain in rats.
BACKGROUND Two major neurotransmitters, gamma-aminobutyric acid (GABA) and the excitatory amino acid, glutamate, may be involved in nociception in the spinal cord. GABA and glutamate receptors may operate in concert to modify signals in the central nervous system. The purpose of this study was to investigate the spinal analgesic interaction between midazolam, a benzodiazepine-GABA(A) receptor a...
متن کاملEffects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol.
AIM To study the effects of intrathecal (it) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors and NMDAR1 antisense oligodeoxynucleotides (AS ODN) on the antinociception of propofol. METHODS Hot-plate test (HPPT) and acetic acid-induced writhing test were used to measure the nociceptive thresholds in mice. Th...
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Background. Many mechanisms are involved in pain transmission in the spinal cord. Therefore, combination of drugs acting on different kinds of mechanisms might be useful for analgesia. We investigated the interaction betweenγ-aminobutyric acid （GABA）B receptor agonist, baclofen, and N-methyl-D-aspartate （NMDA） receptor antagonist, AP-5, orα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ...
متن کاملCan Novel AMPA and NMDA Receptor Antagonists Induce Analgesia?
The glutamate receptors in the nervous system are related to nociceptive response. These receptors include the AMPA (a -amino-3-hydroxy-5-methyl-4isoxazolepropionate) receptor and the NMDA (N-methyl-D-aspartate) receptor1). The purpose of this study was to investigate whether novel antagonists of these glutamate receptors could inhibit the nociceptive response in the spinal cord of male Wistar ...
متن کاملIntrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats
Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2001
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03019761