Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex
نویسندگان
چکیده
منابع مشابه
Epigenetics of the Synaptonemal Complex
Meiosis is a process composed of two divisions of the germ line cells without an intervenient S phase, thus there is no duplication of DNA between the first and the second meiotic divisions. The first meiotic division begins with the pre-leptotene that is the stage where the DNA replicates and chromosomes prepare to enter the meiotic prophase I in most of the organisms with sexual reproduction ...
متن کاملThe synaptonemal complex and the achiasmatic condition.
The onion species AUium amplectans includes both a triploid and a tetraploid variety. By light microscopy both varieties appear to have normal synapsis during pachytene of meiosis. However, the triploid does not form chiasmata and exhibits almost total asynapsis following pachytene. The tetraploid forms at least one chiasma per homologue and retains pairing through metaphase I. Electron-microsc...
متن کاملHeterochromatin, the synaptonemal complex and crossing over.
A combined light- and electron-microscopic examination of chromosomes from two angiospermous plants, Plantago ovata and Lycopersicon esculentum, and a mammal, Mus musculus, was performed. From this investigation three observations have been made that may be relevant to the observed lack of crossing over in heterochromatin. (1) Differential staining indicates that heterochromatin represents a sm...
متن کاملMouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis
During meiosis, the arrangement of homologous chromosomes is tightly regulated by the synaptonemal complex (SC). Each SC consists of two axial/lateral elements (AEs/LEs), and numerous transverse filaments. SC protein 2 (SYCP2) and SYCP3 are integral components of AEs/LEs in mammals. We find that SYCP2 forms heterodimers with SYCP3 both in vitro and in vivo. An evolutionarily conserved coiled co...
متن کاملThe cohesin REC8 prevents illegitimate inter-sister synaptonemal complex assembly.
During meiosis, a specialized chromosome structure is assembled to promote pairing/ synapsis of homologous chromosomes and meiotic recombination, a process yielding chiasmata between homologs to ensure accurate segregation. Meiosis-specific cohesin complexes mediating sister chromatid cohesion play pivotal roles in almost all these events, including synaptonemal complex (SC) formation. In this ...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2017
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-016-0354-6