Synaptic vesicle structure

Synaptic vesicle structure

Moving cel ls l ink membrane and act in E xocytosis and actin polymerization during cell movement are tied together by Xiaofeng Zuo, Wei Guo (University of Pennsylvania, Philadelphia, PA), and colleagues. They fi nd that Exo70, a component of the exocytosis machine called the exocyst, binds to the Arp2/3 complex, a regulator of actin polymerization that helps push out the front of migrating cel...

Structure of proteins involved in synaptic vesicle fusion in neurons.

The fusion of vesicles with target membranes is controlled by a complex network of protein-protein and protein-lipid interactions. Structures of the SNARE complex, synaptotagmin III, nSec1, domains of the NSF chaperone and its adaptor SNAP, and Rab3 and some of its effectors provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models.

Structure of synaptogyrin (p29) defines novel synaptic vesicle protein

Synaptogyrin (p29) is a synaptic vesicle protein that is uniformly distributed in the nervous system (Baumert et al., 1990). We have cloned and sequenced the cDNA encoding synaptogyrin, and the sequence predicts a protein with a molecular mass of 25,900 D with four membrane-spanning domains. The topology of the protein was confirmed by limited proteolysis using domain-specific antibodies. Datab...

Dissecting Synaptic Vesicle Endocytosis

Synaptic vesicle endocytosis.

Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process. In addition, growing evidence suggests that lipids, primarily phosphoinositides, play an important role in synaptic...