منابع مشابه
Synaptic Ribbon Conveyor Belt or Safety Belt?
The synaptic ribbon in neurons that release transmitter via graded potentials has been considered as a conveyor belt that actively moves vesicles toward their release sites. But evidence has accumulated to the contrary, and it now seems plausible that the ribbon serves instead as a safety belt to tether vesicles stably in mutual contact and thus facilitate multivesicular release by compound exo...
متن کاملProperties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles.
Vesicle release from rod photoreceptors is regulated by Ca(2+) entry through L-type channels located near synaptic ribbons. We characterized sites and kinetics of vesicle release in salamander rods by using total internal reflection fluorescence microscopy to visualize fusion of individual synaptic vesicles. A small number of vesicles were loaded by brief incubation with FM1-43 or a dextran-con...
متن کاملThe synaptic ribbon is a site of phosphatidic acid generation in ribbon synapses.
Ribbon synapses continuously transmit graded membrane potential changes into changes of synaptic vesicle exocytosis and rely on intense synaptic membrane trafficking. The synaptic ribbon is considered central to this process. In the present study we asked whether tonically active ribbon synapses are associated with the generation of certain lipids, specifically the highly active signaling phosp...
متن کاملSynaptic Connectivity series Structure and function of ribbon synapses
Sensory neurons with short conduction distances can use nonregenerative, graded potentials to modulate transmitter release continuously. This mechanism can transmit information at much higher rates than spiking. Graded signaling requires a synapse to sustain high rates of exocytosis for relatively long periods, and this capacity is the special virtue of ribbon synapses. Vesicles tethered to the...
متن کاملSynaptic Ribbon Plasticity in Utricular and Saccular Maculae: a Paradox
Research into the effects of weightlessness on rat vestibular maculae has consistently shown that ribbon synapses in hair cells of the utricular maculae exhibit statistically significant changes in number, kind, and distribution when rats are exposed to space flight (Ross, 1993, 1994, 2000). Synaptic plasticity was most evident when all type II hair cells of these maculae were considered and wa...
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ژورنال
عنوان ژورنال: Neuron
سال: 2003
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(03)00062-x