Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
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منابع مشابه
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related tauopathies, but earlier pathologies may herald disease onset. To investigate this, we studied wild-type and P301S mutant human tau transgenic (Tg) mice. Filamentous tau lesions developed in P301S Tg mice at 6 months of age, and progressively accumulated in association with striking neuron loss as well as hippocamp...
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ژورنال
عنوان ژورنال: Neuron
سال: 2007
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2007.03.022