منابع مشابه
Sedative-Hypnotic and Anxiolytic Drugs
The primary use of sedative–hypnotic and anxiolytic drugs is to encourage calmness (anxiolytics or sedatives) or to produce sleep (sedative–hypnotics). All people are subject to states of emotional tension and uneasiness. For otherwise healthy individuals, these occasions are usually sufficiently mild and short that pharmacological intervention is unnecessary. However, at times the symptoms of ...
متن کاملSeparation of Sedative – Hypnotic Drugs with Mixed Micellar Liquid Chromatography
Separation of ten sedative- hypnotic drugs was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, type and amount of organic modifier in mobile phase on efficiency (N) and asymmetry factor (B/A) showed that, the appropriate conditions for a good separation were 35°C and 7% (V/V) butanol in mobile phase. Variations of selectivity factor versus butanol concent...
متن کاملCortical evoked response audiometry thresholds and neuroleptic, sedative, hypnotic drugs.
Cortical evoked response audiometry is adequate for approximating hearing threshold levels with frequency specificity when the psychoacoustic responses lack reliability and reproducibility (compensation claim). It is well-known that control of wakefulness is essential for the reliability of slow vertex responses (SVR). Therefore, sedative, hypnotic, and neuroleptic drugs are supposed to have po...
متن کاملAre extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?
High-affinity extrasynaptic GABA(A) receptors are persistently activated by the low ambient GABA levels that are known to be present in extracellular space. The resulting tonic conductance generates a form of shunting inhibition that is capable of altering cellular and network behavior. It has been suggested that this tonic inhibition will be enhanced by neurosteroids, antiepileptics, and sedat...
متن کامل155 - Sedative-Hypnotic Agents
Barbiturates were formerly the primary sedative-hypnotic agents used clinically. Currently, they are most often encountered as anticonvulsants, induction agents for anesthesia, and agents used for procedural sedation. Because the barbiturates have largely been replaced clinically by benzodiazepines due to safety concerns, their prevalence in overdoses has drastically decreased when compared wit...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1956
ISSN: 0007-0912
DOI: 10.1093/bja/28.1.19