Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice

Abstract Tissue regeneration is a process that recapitulates and restores organ structure function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice ( Mus ), the limited to center of wound unlike those observed African spiny Acomys ) mice. mechanics been implicated as an integral part tissue morphogenesis. Here, we use WIHN model investigate mechanical molecular responses mice, report these models demonstrate opposing trends spatiotemporal morphogenetic field formation with association stiffness landscapes. Transcriptome analysis K14-Cre-Twist1 transgenic show Twist1 pathway acts mediator for both epidermal-dermal interactions competence factor periodic patterning, differing from used development. We propose Turing based on supports two-scale process: (1) establishing within bed (mm scale) (2) symmetry breaking epidermis forming periodically arranged primordia (?m scale). Thus, delineate distinct chemo-mechanical events building morphogenesis-competent during identify its evo-devo advantages perspectives regenerative medicine.