Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP

How organisms control organ size is not fully understood. We found that Syd/JIP3 required for proper wing in Drosophila. JIP3 mutations are associated with defects mammals. The underlying mechanisms well discovered inhibition results a downregulation of the inhibitor apoptosis protein 1 (Diap1) Drosophila wing. Correspondingly, deficient tissues exhibit ectopic cell death and yield smaller wings. generated similar effects mammalian cells, indicating conserved mechanism. Yorkie/YAP stimulates cells. Notably, full effect Yorkie-mediated tissue growth. Thus regulation Diap1 functions downstream to This study provides mechanistic insights into recent perplexing link between mammals, including humans where de novo variants microcephaly.