Switching From Donepezil to Rivastigmine Is Well Tolerated

Switching from donepezil tablets to rivastigmine transdermal patch in Alzheimer's disease.

OBJECTIVE Evaluate safety and tolerability of switching from donepezil to rivastigmine transdermal patch in patients with mild to moderate Alzheimer's disease. METHODS Prospective, parallel-group, open-label study to evaluate immediate or delayed switch from 5-10 mg/day donepezil to 4.6 mg/24 h rivastigmine following a 4-week treatment period. RESULTS Rates of discontinuation due to any rea...

Patient tolerated procedure well.

Appendices: Donepezil, rivastigmine, galantamine and memantine for Alzheimer’s disease

Systemic Inhibition of CREB is Well-tolerated in vivo

cAMP-response element binding protein (CREB) is a nuclear transcription factor activated by multiple extracellular signals including growth factors and hormones. These extracellular cues activate CREB through phosphorylation at Ser133 by various protein serine/threonine kinases. Once phosphorylated, it promotes its association with transcription coactivators CREB-binding protein (CBP) and its p...

Nivolumab Is Well Tolerated and Active in Patients with Lymphoma.

PD-1 blockade with nivolumab was safe and achieved objective responses in patients with lymphoma.