Switched-on chromatin

THE EFFECT OF MECHLOROETHAMIN ON RECONSTITUTED CHROMATIN

In this study the effect of a methylated derivative of nitrogen mustard (mechloroethamin) on solubilized and reconstituted chromatin was investigated using UVNis spectroscopy, DNA and SDS gel electrophoresis and densitomeoic scanning techniques, The results indicated that the 210 and 260 nm absorbances of reconstituted chromatin were decreased in a dose-dependent manner after treatment wit...

THE EFFECT OF ADRIAMYCIN ON SALT FRACTIONATED CHROMATIN

In this study calf thymus chromatin was fractionated into active (S1 and S2) and inactive (P 2) chromatin. Then the interaction of an anthracyc1ine antibiotic, adriamycin, with these fractions was investigated employing absorption and difference UV Nis spectroscopy and SDS and agarose gel electrophoreses. The results suggest that the binding of adriamycin to the S 1 fraction is slight but ...

Transcriptional control: SWItched-on mobility

Dynamic changes in chromatin structure underlie much of transcriptional control in the eukaryotic nucleus. In the hope of understanding how these are effected, attention has focused on the molecular machines that reorganize chromatin. The best-defined of these machines contain members of the SWI2/SNF2 superfamily of ATPases. These enzymes use the energy of ATP hydrolysis to destabilize chromati...

On Duality of Switched DAEs

Study on switched reluctance generator.

The linear and non-linear math models of the switched reluctance generator (SRG) in generator mode were established in this work. The phase current and energy conversion process during generator operation were simulated by the linear math model. The non-linear math model was used to analyze the characteristics of the SRG operation in self-excitation mode and in separately-excitation mode. Some ...