SWISS-MODEL: an automated protein homology-modeling server

SWISS-MODEL: an automated protein homology-modeling server

SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-MODEL provides several levels of user inte...

Structure Homology Modeling of Thaumetopoein, an Urticating Protein from Thaumetopoea pityocampa Schiff, Using SWISS-MODEL Workspace

Background Thaumetopoea pityocampa Schiff., or pine caterpillar, is a “phenomenal” insect. The term comes from the Greek cámpa (caterpillar), pítys (pine), poieo (does), tháuma (wonders) [1]. When developing larvae, is taking place on the back of the caterpillar pine processionary, a producer apparatus urticating hairs, protectors caterpillars [2]. These hairs of the pine processionary caterpil...

RosettaAntibody: antibody variable region homology modeling server

The RosettaAntibody server (http://antibody.graylab.jhu.edu) predicts the structure of an antibody variable region given the amino-acid sequences of the respective light and heavy chains. In an initial stage, the server identifies and displays the most sequence homologous template structures for the light and heavy framework regions and each of the complementarity determining region (CDR) loops...

COMA server for protein distant homology search

SUMMARY Detection of distant homology is a widely used computational approach for studying protein evolution, structure and function. Here, we report a homology search web server based on sequence profile-profile comparison. The user may perform searches in one of several regularly updated profile databases using either a single sequence or a multiple sequence alignment as an input. The same pr...

Probabilistic protein homology modeling