"SUSTAINED RELEASE FORMULATIONS OF METOPROLOL TARTARATE USING HYDROPHILIC MATRIX SYSTEM"

Formulation and Evaluation of Sustained Release Metoprolol Succinate Tablet using Hydrophilic gums as Release modifiers

The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol succinate using natural hydrophilic gums such as karaya gum and xanthan gum as a release modifier. Nine batches were prepared by using karaya gum (KG) and xanthan gum (XG) in concentration of 15%, 20% and 25% alone and in combination of 2:8. Matrix tablets were prepared by wet granulation m...

Health expenditure comparison of extended-release metoprolol succinate and immediate-release metoprolol tartarate

BACKGROUND Metoprolol, a selective beta-1 blocker, is available in two different salt forms in the market - metoprolol succinate (MS) and metoprolol tartarate (MT). Both the formulations are Food and Drug Administration approved for the treatment of hypertension. Several studies have shown similar efficacies between the two salts; however, they differ in their pharmacokinetic properties and are...

Formulation, Evaluation and Optimization of Sustained Release Tablets of Indapamide using Hydrophilic Matrix system

Different formulations of Indapamide 1.5mg sustained release tablets were formulated using wet granulation method using hydrophilic polymer. The tablets were subjected to physicochemical studies, in vitro release studies, kinetic modeling and stability studies to find out the best formulation. The in vitro release studies were conducted for 16 hours using USP 30 apparatus type I (Basket method)...

preparation and evaluation of zinc sulfate sustained release tablets using lipophilic and hydrophilic matrix

Hydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide

Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...