Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused?
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چکیده
منابع مشابه
Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused?
BACKGROUND Surrogate outcomes are not intrinsically beneficial to patients, but are designed to be easier and faster to measure than clinically meaningful outcomes. The use of surrogates as an endpoint in clinical trials and basis for regulatory approval is common, and frequently exceeds the guidance given by regulatory bodies. DISCUSSION In this article, we demonstrate that the use of surrog...
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ژورنال
عنوان ژورنال: BMC Medicine
سال: 2017
ISSN: 1741-7015
DOI: 10.1186/s12916-017-0902-9