Surfactant protein D in human lung diseases

Structural characterization of human and bovine lung surfactant protein D.

Human and bovine surfactant proteins D (SP-D) were purified from late amniotic fluid and bronchioalveolar lavage on the basis of its Ca(2+)-dependent affinity for maltose. The molecular mass of a trimeric subunit was determined by matrix-assisted laser desorption ionization MS to lie in the range 115-125 kDa for human SP-D and 110-123 kDa for bovine SP-D. A single polypeptide chain was determin...

Surfactant Protein D in Respiratory and Non-Respiratory Diseases

Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts antimicrobial effects and dampens inflammation through direct microbial interactions and modulation of host cell responses via a series of cellular receptors. However, low protein concentrations, genetic variation, biochemic...

Surfactant Protein D Inhibition of Human

Surfactant protein D: not just for the lung anymore.

IN THEIR ARTICLE, Snyder et al. (5) provide compelling data that arterial smooth muscle cells of the vessel wall express surfactant protein D (SP-D) and that the expression of SP-D attenuates the release of IL-8 stimulated by LPS and TNF. Although most often associated with innate immune protection of the lung, the authors show clearly that arterial smooth muscle cells express SP-D and that SP-...

Mucosal Surfaces in Human Tissues Localization of Lung Surfactant Protein D on