Surface Charge Density Determines the Efficiency of Cationic Gemini Surfactant Based Lipofection

The Effect of Cationic Charge Density Change on Transfection Efficiency of Polyethylenimine

Asp-Gly based peptides confined at the surface of cationic gemini surfactant aggregates.

Cationic gemini surfactants complexed with anionic oligoglycine-aspartate (called gemini peptides hereafter) were synthesized, and their aggregation behaviors were studied. The effects of the hydrophobic chain length (C10-C22) and the length of the oligoglycine (0-4) were investigated, and it was clearly shown by critical micellar concentration, Krafft temperature, and isothermal surface pressu...

Spontaneous aggregate transition in mixtures of a cationic gemini surfactant with a double-chain cationic surfactant.

Controllable aggregate transitions were realized by mixing two kinds of cationic surfactants, hexylene-1,6-bis(dodecyldimethylammonium bromide) (C(12)C(6)C(12)Br(2)) and didodecyldimethylammonium bromide (DDAB). It was found that two parameters are the main factors determining the aggregation behavior of the mixed system, the total concentration of DDAB and C(12)C(6)C(12)Br(2) (C(T)), and the m...

Biophysical Studies on the Interaction of Insulin with a Cationic Gemini Surfactant

A novel quaternary ammonium-based cationic gemini surfactant (S6) having 1,6 di-bromo hexane as a spacer, have been used and its interaction with insulin in aqueous solution (pH, 7.40) was investigated by several methods including fluorescence spectroscopy, UV-Vis spectroscopy, circular dichroism, dynamic light scattering, ζ-potential measurements, conductivity and transmission electron microsc...

the effect of cationic charge density change on transfection efficiency of polyethylenimine

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