Supramolecular engineering of hydrogels for drug delivery

Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where being used drug delivery systems: engineering network mechanics and tailoring drug–material affinity. Throughout, many established emerging chemistries useful for applications.