Suppression of Inflammatory Cytokines During Ex Vivo Lung Perfusion With an Adsorbent Membrane
نویسندگان
چکیده
منابع مشابه
normothermic ex vivo lung perfusion in brain-dead donors reduces inflammatory cytokines and toll-like receptor expression
inflammatory responses and innate immunologic reactions play an important role in the respiratory system. ex vivo lung perfusion (evlp) is considered a novel method in the evaluation and reconditioning of donor lungs prior to transplantation. however, evlp’s effect on inflammatory and metabolic markers of human lung tissue is unknown. this study investigated how the performance of evlp on brain...
متن کاملAntagonizing reactive oxygen species during ex vivo lung perfusion.
TO THE EDITOR: The stop of flow (ischemia) would be interpreted as membrane depolarization, through the inhibition of KATP channels, leading to activation of NADPH oxidase, leading to increased reactive oxygen species (ROS) production (1). The resultant ROS are claimed to be an effective mediator for ischemic preconditioning (IPC), as proved by the observation that the presence of antioxidants ...
متن کاملEx vivo lung perfusion in Brazil
OBJECTIVE To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. METHODS A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for u...
متن کاملNormothermic Ex Vivo Lung Perfusion in Brain-dead Donors Reduces Inflammatory Cytokines and Toll-like Receptor Expression.
Inflammatory responses and innate immunologic reactions play an important role in the respiratory system. Ex vivo lung perfusion (EVLP) is considered a novel method in the evaluation and reconditioning of donor lungs prior to transplantation. However, EVLP's effect on inflammatory and metabolic markers of human lung tissue is unknown. This study investigated how the performance of EVLP on brai...
متن کاملTowards a better understanding of ex vivo lung perfusion.
Ex vivo lung perfusion (EVLP) is probably the most promising technique currently available to substantially increase the number of acceptable donor lungs and to improve the outcome after lung transplantation. Several ongoing prospective single and multicentre trials are currently investigating the potential and the individual advantages of different platforms available for EVLP. So far, a numbe...
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ژورنال
عنوان ژورنال: The Annals of Thoracic Surgery
سال: 2010
ISSN: 0003-4975
DOI: 10.1016/j.athoracsur.2010.02.077