Suppression of ID1 expression in colon cancer cells increases sensitivity to 5-fluorouracil
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چکیده
منابع مشابه
Suppression of ID1 expression in colon cancer cells increases sensitivity to 5-fluorouracil.
Adjuvant chemotherapy with 5-fluorouracil remains the basic treatment for patients with advanced colorectal carcinoma. The major obstacle in successful treatment is the ability of CRC cells to acquire chemoresistance. Here we examined the impact of ID1 silencing on the sensitivity of CRC cells to 5-FU. To suppress ID1 expression in HT-29 and HCT-116 cells the cells were transduced with a lentiv...
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PURPOSE Dihydropyrimidine dehydrogenase (DPD), the initial rate-limiting enzyme in the degradation of 5-fluorouracil (5-FU), is known to be a principal factor in clinical responses to the anticancer agent 5-FU, and various reports have clearly demonstrated that DPD activity is closely correlated to mRNA levels. However, the regulatory mechanisms of DPD gene (DPYD) expression remain unclear. In ...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2017
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2016_1421