Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates
نویسندگان
چکیده
We report a new electrochemical supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. This simple, practical, phosgene-free route includes generation an isocyanate intermediate in situ anodic decarboxylation acid presence organic base, followed by one-pot addition suitable nucleophiles to afford corresponding thiocarbamates. procedure is applicable different amines, alcohols, thiols. Furthermore, when single-pass continuous flow conditions were used this reaction was run carbon graphite Cgr/Cgr cell, urea compounds could be obtained high yields within residence time 6 min, unlocking access substrates that inaccessible under batch while being easily scalable.
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ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2021
ISSN: ['1083-6160', '1520-586X']
DOI: https://doi.org/10.1021/acs.oprd.1c00112