Supersolubility of Diphenylhydantoin Sodium
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چکیده
منابع مشابه
Diphenylhydantoin inhibition of sodium conductance in squid giant axon.
Diphenylhydantoin, in concentration of 5-50 muM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.
متن کاملEffect of diphenylhydantoin on synaptosome sodium-potassium-ATPase.
Previous studies have demonstrated that electrically induced seizures in rat result in an increased brain intracellular sodium which can be decreased by treatment with sodium diphenylhydantoin (DPH). The correlation of cation transport with membrane-oriented sodium-potassium-adenosine triphosphatase (Na-K-ATPase) prompted an investigation of the effect of DPH upon ATPase enzyme activity.Rat cer...
متن کاملThe Effect of Diphenylhydantoin
This work was previously published in abstract form in Clin. Res. 17: 288, 1969. Dr. Larsen's present address is the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa. 15213. Received for publication 10 November 1969 and in revised form 4 February 1970. concentration. If free thyroxine is the only portion of the hormone available for cellular utilization, then ...
متن کاملProtection from Digitalis Toxicity with the Prophylactic Use of Diphenylhydantoin Sodium
Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%. At constant heart rates, pretreatment with diphenylhydantoin sodium did not alter the elevation of rate of rise of left ventricular pressure produced by the glycoside. Two implications have been drawn from these findings. First, the inotropic and arrhythmic act...
متن کاملBlockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites.
Cardiac toxicity is a frequent manifestation in amitriptyline overdose and is felt to be due, in part, to sodium channel blockade by the drug. Another agent with sodium channel blocking properties, diphenylhydantoin, has been used clinically to reverse cardiac conduction abnormalities induced by amitriptyline. This reversal of toxicity is believed to occur secondary to competition for the sodiu...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1955
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.75.8_985