Sumatriptan-induced saphenous venoconstriction in the anaesthetized dog through 5-HT1-like receptor activation
نویسندگان
چکیده
منابع مشابه
Sumatriptan and venoconstriction.
The paper by MB Vincent et 31. in this issue represents a further piece of investigation on the mechanism of action of sumatriptan. It focuses on the efficacy of the drug in aborting cluster headache ( CHj attacks, a clinical condition for which sumatriptan is highly effective and now represents the treatment of choice. The authors have chosen porcine ophthalmic artery ( POAj for evaluating the...
متن کاملParticipation of 5-HT1-Like Receptors and 5-HT2 Receptors in Serotonin-Induced Contraction of Human Isolated Coronary Arteries 5-HT1-Like Receptors Resemble Cloned 5-HT1Dp Receptors
Background Serotonin may contract human large coronary arteries through two 5-hydroxtryptamine (5-HT) receptors, 5-HT1-like and 5 -HT2. These 5-HT1-like receptors resemble both cloned 5-HT1D receptor subtypes, 5-HT'1D, and 5 -HT1Ds. Although these subtypes have similar pharmacology, 5-HT1Dg receptors appear to have lower affinity for ketanserin than 5-HT1Di receptors. We assessed the relative p...
متن کاملAltered oesophageal motility following the administration of the 5-HT1 agonist, sumatriptan.
BACKGROUND The 5-HT1 agonist sumatriptan, used in the treatment of migraine, can cause chest pain. AIM To investigate the effect of a therapeutic dose of sumatriptan (6 mg s.c.) on oesophageal motility. METHODS In 16 normal healthy subjects aged 19-32 years (9 males), the manometric response of the lower oesophageal sphincter (sleeve sensor), oesophageal body (four sites), stomach and phary...
متن کاملRepression of the calcitonin gene-related peptide promoter by 5-HT1 receptor activation.
We have investigated the control of calcitonin gene-related peptide (CGRP) expression by a serotonergic agonist that is related pharmacologically to currently used antimigraine drugs. During migraines, CGRP levels are elevated but then returned to normal by a 5-HT1 receptor agonist, sumatriptan. However, neither the molecular nor cellular targets of this drug are known. Trigeminal neurons are t...
متن کاملHaemodynamic effects of labetalol-induced hypotension in the anaesthetized dog.
Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg-1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1995
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1995.tb15055.x