Sulphydryl Groups and Tumour Induction by Chemical Agents
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چکیده
منابع مشابه
Studies on induction by substances containing sulphydryl groups in post-nodal pieces of chick blastoderm.
The importance of sulphydryls in morphogenesis is being increasingly recognized. In the study of the role of thiols in amphibian and avian development one of the methods of approach has been to subject early embryonic stages to the action of reagents such as chloroacetophenone, monoiodoacetic acid, oxidized glutathione and mercaptoethanol (Beatty, 1949; Rapkine & Brachet, 1951; Deuchar, 1957; B...
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Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. It is inferred that intact sulphydryl groups are essential for constancy of responses of excitable tiss...
متن کاملThe sulphydryl groups of sickle-cell haemoglobin.
particularpH owing to the screening ofthe haematin iron atom from the influence of the various ionizing groups. On this basis a larger critical I would signify that a larger concentration of salt ions is required for complete screening, and hence that there is a stronger interaction between the iron and the ionizing groups in MetHb. In conclusion, although the mechanism may be different it may ...
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Dog hemoglobin has four sulphydryl groups at positions olfl (G18) and p93 (F9), all of which are titratable with mercurials. Only two of these, however, react with non-mercurial sulphydryl reagents. Kinetic results indicate that the reacting site might be the p”” (F9). An examination of the environment of the alI1 (G18) shows that this sulphydryl must be unreactive towards non-mercurials becaus...
متن کاملHistochemical Methods for Protein-bound Sulphydryl and Disulphide Groups By G. GOMORI
Histochemical methods for the localization of protein-bound sulphydryl groups were compared in a critical fashion. As far as localization is concerned, several of the methods published were found to be satisfactory. However, from the point of view of approximate visual quantitation, the results are confusing. The two best methods for the histochemical detection of protein-bound sulphydryl group...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1961
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1961.76