Sulfondiimidamides as new functional groups for synthetic and medicinal chemistry

•Efficient three-component assembly of sulfondiimidamides; new analogs sulfonamides•Use unsymmetrical sulfurdiimide reagents is key to success the synthesis•Broad variation at all three nitrogen atoms and carbon substituent•Preparation enantiomerically enriched, chiral sulfur, examples A functional group an arrangement that defines topology reactivity a molecule. The ability modify these two parameters in useful predictive ways foundation synthetic organic chemistry accounts for wide-ranging applications enjoyed by molecules. For example, medicinal chemists often tune substituents attached specific groups as they explore chemical space, searching biologically active Sulfonamides have long history chemistry, with first important examples, “sulfa drugs,” being described 1930s. Here, we report group, sulfondiimidamides, which are double aza sulfonamides. We show molecules stable, can be efficiently prepared, precise manipulation functionalization possible. 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