منابع مشابه
Resistance to trimethoprim and sulfonamides.
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing drug-insensitive variants of the target enzymes dihydropteroate synthase and dihydrofolate reductase, for sulfonamide and t...
متن کاملCharacterization of transferable plasmids from Shigella flexneri 2a that confer resistance to trimethoprim, streptomycin, and sulfonamides.
A set of plasmids conferring resistance to several antibiotics, including the combination of trimethoprim and sulfamethoxazole, has been isolated from Escherichia coli following conjugative cotransfer from a clinical isolate of Shigella flexneri 2a. One of the plasmids, pCN1, was shown by subcloning and DNA sequencing to carry a gene encoding a trimethoprim-insensitive dihydrofolate reductase i...
متن کاملTuberculosis and trimethoprim-sulfamethoxazole.
The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunoco...
متن کاملAllergy to sulfonamides.
CLINICAL VIGNETTE A 48-year-old man was referred to our clinic with high-grade intermittent fever for 8 days and a generalized rash for 3 days. Threeweeks before presentation, the patient had been started on 5 mg/d prednisolone, 50 mg of diclofenac twice daily, 20 mg/d omeprazole, and 2 g/d of sulfasalazine for symptomatic ankylosing spondylitis. During the initial evaluation, he was febrile (3...
متن کاملOral Antidiabetic Sulfonamides
In October 1955 three reports in the Deutsche Medizinische Wochenschrift' described a new sulfonamide derivative possessing the ability when given by mouth to reduce normal blood sugar values to subnormal, and elevated blood and urine sugar values in diabetes to normal. Reduction of normoglycemia had been shown with other sulfonamide derivatives as early as 1942," but the application to therapy...
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ژورنال
عنوان ژورنال: Expert Review of Anti-infective Therapy
سال: 2010
ISSN: 1478-7210,1744-8336
DOI: 10.1586/eri.09.117