SULFOLIPID FROM VIRULENT TUBERCLE BACILLI

Relative permissiveness of macrophages from black and white people for virulent tubercle bacilli.

Epidemiological, clinical, and histopathological evidence suggests that black people are more susceptible to tuberculosis than are white people. The cellular basis of this putative susceptibility was investigated in vitro by comparing responses of blood-derived macrophages from black and white donors to experimental infection with virulent tubercle bacilli. Phagocytes from pairs of black and wh...

Cultivation of Tubercle Bacilli from Pleural Fluid

The diand tri-peptidase activity in white blood cells showed little variation from day to day (Table 11). This variation bore no relation to the changes in the number of white blood cells per c.mm. observed in cases of leukaemia. However, the activity of the enzymes differed in the diverse types ofwhite blood cells examined. White blood cells from cases of acute and chronic myeloid leukaemias g...

Cellular Reactions to Polysaccharides from Tubercle Bacilli and from Pneumococci

1. Purified tuberculo-polysaccharides are relatively innocuous both to normal and to tuberculous guinea pigs. 2. Both tuberculo-polysaccharides and polysaccharides from pneumococci call larger numbers of leucocytes from the blood vessels than do saline and dextrose and trehalose. 3. The mechanisms controlling the delivery of lymphocytes and neutrophils into the blood stream are different. 4. Sl...

Streptomycin sensitivity of tubercle bacilli from resected lungs.

Cellular Reactions to Fractions Isolated from Tubercle Bacilli

The cellular reactions in tuberculosis form one of the striking features of the disease and it is important to note that they can be produced by the dead bacilli. In 1890, Maffucci (1) studied the effect of subcutaneous injections of dead organisms; he recorded the formation of abscesses and the subsequent death of the animals from marasmus. The next year, Koch (2), in the well-known article de...