منابع مشابه
Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s.
Human liver microsomes catalyze the oxidation of sulfinpyrazone sulfide (SPZS) to a variable mixture of sulfinpyrazone (SPZ) enantiomers and two minor phenolic metabolites. In one, the thiophenyl ring is hydroxylated, whereas in the second an N-phenyl ring is hydroxylated. SPZ is further oxidized to sulfinpyrazone sulfone (SPZO) and a minor polar metabolite that also has an N-phenyl ring hydrox...
متن کاملEffects of Clofibrate and Sulfinpyrazone
Platelet survival time was measured (autologous labelling with 51chromium) in 68 men with coronary artery disease (CAD). Survival was shortened slightly (3.2 ± 0.04 days; mean ± SEM) as compared to normal (3.7 ± 0.04 days; N = 18; P < 0.001), and 60% had shortened survival (< 3.3 days). Thirty-seven had hyperlipoproteinemia (36 with Type IV and one with Type III) and platelet survival was short...
متن کاملEffect of sulfinpyrazone on ventricular fibrillation during acute myocardial ischemia.
In patients treated with sulfinpyrazone, an apparent reduction in the incidence of sudden death and presumed ventricular fibrillation has been reported. Using an intact animal model without microcirculatory thrombosis, we studied the effects of sulfinpyrazone on ischemic myocardium in 58 anesthetized dogs divided into three groups: control untreated (n =24), group 1 (n = 16), treated daily with...
متن کاملThe Role of Sulfinpyrazone in the Prevention of Arterio - venous
as a double-blind crossover study but it was decided to carry out an interim analysis at the time when every patient had completed the first part of the crossover design, mainly because of the potential hazard of platelet suppressive drugs in patients with renal failure. The results of this interim analysis showed that not only was the drug safe but that there was a significant benefit of sulfi...
متن کاملStereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man.
Although serious hemorrhage during therapeutic coadministration of sulfinpyrazone and racemic warfarin occurs, no prospective studies have been done. In this study, single oral doses of racemic warfarin, 1.5 mg/kg, were administered to six normal subjects with and without oral sulfinpyrazone, 400 mg daily. Both the hypoprothrombinemia (p less than 0.001) and the plasma warfarin concentrations (...
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ژورنال
عنوان ژورنال: Circulation
سال: 1981
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.63.4.970