Sulfhydryl reagents trigger noradrenaline release from rat brain slices
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چکیده
منابع مشابه
Neomycin inhibits K+- and veratridine-stimulated noradrenaline release in rat brain slices and rat brain synaptosomes.
The possible involvement of phosphoinositides' turnover in the process of neurotransmitter release in the central nervous system (CNS) was studied using rat brain slices and synaptosomes. A depolarizing concentration of potassium chloride (25 mM) induces an 8.6 +/- 0.4% increase of [3H]noradrenaline [( 3H]NA) fractional release in cerebral cortical slices above spontaneous release, and 15 mM KC...
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This study was designed to test the hypothesis of whether activation of presynaptic P2X receptor-gated ion channels elicits noradrenaline release from central catecholaminergic terminals. ATP, alpha,beta-methylene-adenosine 5'-triphosphate (alpha,beta-methyleneATP), and ADP elicited concentration-dependent [3H]noradrenaline outflow from superfused rat hippocampal slices with the following rank ...
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The modulation of noradrenaline (NA) release via presynaptic opioid receptors in the hippocampus of freely moving rats was studied by the use of brain microdialysis. Extracellular levels of NA were estimated by assaying its concentrations in the perfusion fluid using high-performance liquid chromatography (HPLC) with electrochemical detection (ECD). Spontaneous NA levels were reduced by tetrodo...
متن کاملIncrease in ACh release from the rat brain cortex slices by 3',5'-cyclic adenosine monophosphate.
It is known that activities of adenylate cyclase and cyclic nucleotide phosphodiesterase are higher in brain tissue than in other tissues (1-3), and regulatory roles of 3',5'-cyclic adenosine monophosphate (cyclic AMP) on brain function have been reported by several workers (4-11). On the other hand, it has been observed that secretion of many kinds of hormones (12-17) and enzymes (18, 19) is s...
متن کاملLocations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids.
1. Amino acids, particularly glutamate, gamma-aminobutyrate, aspartate and glycine, were released from rat brain slices on incubation with protoveratrine (especially in a Ca(2+)-deficient medium) or with ouabain or in the absence of glucose. Release was partially or wholly suppressed by tetrodotoxin. 2. Tetrodotoxin did not affect the release of glutamine under various incubation conditions, no...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)41126-8