Sulfated Polysaccharides as Specific Biologically Active Materials

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications.

In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae and fucoidan in brown algae. Sulfated polysa...

Intra-axonal injection of biologically active materials.

BRADY, ROSCOE O., CONSTANTINE S. SPYROPOULOS AND ICHITI TASAKI. htra-axonal injection of biologically active materiak n improved method for injection of chemicals into the squid giant axon is described. A large number of metabolically active materials were found to be without any effect upon the action potential. Tetraethylammonium chloride produced a striking prolongation of the action potenti...

Ix. Biologically Active Materials in Soil

Sulfated polysaccharides fucoidans from brown algae

The immunotropic activity of structurally different fucoidans and their derivatives towards isolated immune blood cells, effectors of innate immune system, was studied. The most potent effect was observed for high molecular weight fucoidan CF from the alga Chordaria flagelliformis, whose backbone is built of (1→3)-linked units of α-L-fucopyranose, and branches included residues of α-D-glucuroni...

Effects of sulfated polysaccharides on tumour biology.

Sulfated polysaccharides can act not only as anticoagulants but also as tumour inhibitors. Recent studies suggest that sulfated polysaccharides could affect tumour cells directly. Sulfated polysaccharides could inhibit the metastasis and proliferation of tumour cells by binding to growth factors and cell adhesion molecules. Moreover, sulfated polysaccharides could inhibit heparanase, which clea...