Sulfate radicals enable a non-enzymatic Krebs cycle precursor
نویسندگان
چکیده
منابع مشابه
Primordial Krebs - cycle - like non - enzymatic reactions detected by mass spectrometry and nuclear magnetic resonance
Metabolism is the process of nutrient uptake and conversion, : Background and executed by the metabolic network. Its evolutionary precursors most likely originated in non-enzymatic chemistry. To be exploitable in a Darwinian process that forms a metabolic pathway, non-enzymatic reactions need to form a chemical network that produces advantage-providing metabolites in a single, life compatible c...
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The substrate scope of inverting alkylsulfatase Pisa1 was extended towards benzylic sec-sulfate esters by suppression of competing non-enzymatic autohydrolysis by addition of dimethyl sulfoxide as co-solvent. Detailed investigation of the mechanism of autohydrolysis in 18O-labeled buffer by using an enantiopure sec-benzylic sulfate ester as substrate revealed that from the three possible pathwa...
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ژورنال
عنوان ژورنال: Nature Ecology & Evolution
سال: 2017
ISSN: 2397-334X
DOI: 10.1038/s41559-017-0083