Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of Caenorhabditis elegans
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چکیده
منابع مشابه
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
The beneficial effects of polyphenol compounds in fruits and vegetables are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary polyphenols are beneficial in whole animals, particularly with respect to aging. To address this question, we examined the effects of blueberry polyphenols o...
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nAture methods | ADVANCE ONLINE PUBLICATION | the measurement of lifespan pervades aging research. Because lifespan results from complex interactions between genetic, environmental and stochastic factors, it varies widely even among isogenic individuals. the actions of molecular mechanisms on lifespan are therefore visible only through their statistical effects on populations. indeed, survival ...
متن کاملLifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans.
Caenorhabditis elegans nfi-1 belongs to the Nuclear Factor I (NFI) family of transcription factors known to regulate metazoan gene expression and development. We showed previously that loss of nfi-1 in worms results in multiple behavioral defects; slower pharyngeal pumping rate, impaired egg laying, defective motility, and a shortened life span. Here, we generated cell-type specific transgenic ...
متن کاملRole of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans.
Cytochrome P450 (CYP)-dependent eicosanoids comprise epoxy- and hydroxy-metabolites of long-chain PUFAs (LC-PUFAs). In mammals, CYP eicosanoids contribute to the regulation of cardiovascular and renal function. Caenorhabditis elegans produces a large set of CYP eicosanoids; however, their role in worm's physiology is widely unknown. Mutant strains deficient in LC-PUFA/eicosanoid biosynthesis di...
متن کاملPharyngeal pumping in Caenorhabditis elegans depends on tonic and phasic signaling from the nervous system.
Rhythmic movements are ubiquitous in animal locomotion, feeding, and circulatory systems. In some systems, the muscle itself generates rhythmic contractions. In others, rhythms are generated by the nervous system or by interactions between the nervous system and muscles. In the nematode Caenorhabditis elegans, feeding occurs via rhythmic contractions (pumping) of the pharynx, a neuromuscular fe...
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ژورنال
عنوان ژورنال: Free Radical Research
سال: 2019
ISSN: 1071-5762,1029-2470
DOI: 10.1080/10715762.2019.1661403