Sudden Insensibility after Extreme Muscular Exertion

Sudden death after exertion in apparently healthy boy.

Whole-Exome Molecular Autopsy After Exertion-Related Sudden Unexplained Death in the Young.

BACKGROUND Targeted postmortem genetic testing of the 4 major channelopathy-susceptibility genes (KCNQ1, KCNH2, SCN5A, and RYR2) have yielded putative pathogenic mutations in ≤30% of autopsy-negative sudden unexplained death in the young (SUDY) cases with highest yields derived from the subset of exertion-related SUDY. Here, we evaluate the role of whole-exome sequencing in exertion-related SUD...

Physical exertion, exercise, and sudden cardiac death in women.

CONTEXT Exercise is associated with a lower risk of cardiovascular events but may transiently increase the risk of ventricular arrhythmias. Its short-term and long-term associations with risk of sudden cardiac death among women are unclear. OBJECTIVES To compare the risk of sudden cardiac death in women during moderate to vigorous exertion with the risk of sudden cardiac death during lighter ...

Triggering of sudden death from cardiac causes by vigorous exertion.

BACKGROUND Retrospective and cross-sectional data suggest that vigorous exertion can trigger cardiac arrest or sudden death and that habitual exercise may diminish this risk. However, the role of physical activity in precipitating or preventing sudden death has not been assessed prospectively in a large number of subjects. METHODS We used a prospective, nested case-crossover design within the...

The Effective Stimulus for Increased Pulmonary Ventilation during Muscular Exertion.

The control of the pulmonary ventilation is a central problem in the physiology of muscular exercise. The hypothesis that the respiratory center is stimulated by chemical changes in the arterial blood has been defended by Gesell (1), Haldane (2), and Henderson (3). In addition to this type of stimulation, Krogh and Lindhard (4) have discussed the anticipatory hyperventilation preceding and imme...