Sudden death in epilepsy: An experimental animal model

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Sudden death in epilepsy: An experimental animal model

INTRODUCTION The physiopathogenetic mechanisms possibly involved in sudden unexplained epileptic death (SUDEP), were investigated in the hemispherectomized rat. METHODS For this purpose, paroxysmal activity, vagal nerve firing, systemic blood pressure (BP), pulmonary artery pressure, and ECG were simultaneously recorded in an experimental animal model of epilepsy. Recordings were performed in...

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Sudden Unexpected Death in Epilepsy: An Overview

Vera C. Terra1, Américo C. Sakamoto1, Hélio R Machado1 and Fulvio A. Scorza2 1Centro de Cirurgia de Epilepsia (CIREP). Departamento de Neurociências e Ciências do Comportamento. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Ribeirão Preto, São Paulo, 2Disciplina de Neurologia Experimental. Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), São Pa...

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Alcohol consumption and sudden unexpected death in epilepsy: experimental approach.

Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose o...

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Sudden death and epilepsy.

The diagnosis of epilepsy carries an excess mortality risk which is highest during the first 10 years following diagnosis, particularly during the first 2 year& 2. Some of this may be related to suicide37 4 or accident5-7. Convulsive status epilepticus as a cause of death in people with a diagnosis of epilepsy seems to be a relatively rare phenomenon from childhood until middle adult life, alth...

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Sudden unexpected death in epilepsy

SUDEP is defined as the sudden, unexpected, witnessed or unwitnessed, non-traumatic, and non-drowning death in patients with epilepsy with or without evidence for a seizure, and excluding documented status epilepticus, in which postmortem examination does not reveal a structural or toxicological cause for death1. Where autopsy is not performed, and for the purpose of epidemiological studies, su...

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ژورنال

عنوان ژورنال: Seizure

سال: 2006

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2006.02.007