Successful repigmentation of vitiligo after allogeneic bone marrow transplantation for Hodgkin′s lymphoma by autologous noncultured melanocyte-keratinocyte transplantation

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Generalized vitiligo after allogeneic bone marrow transplantation.

Sir, Vitiligo is a common, depigmenting disorder characterized by well-circumscribed cutaneous macules devoid of melanocytes on the epidermis. Bone marrow transplantation (BMT), which has significant therapeutic benefits in haematologic disorders, such as leukaemia and aplastic anaemia, provides convincing evidence for the role of the immune system in some autoimmune diseases (1). In this repor...

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Long-term follow-up study of segmental and focal vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation.

OBJECTIVE To evaluate long-term efficacy and safety of melanocyte-keratinocyte cell transplantation in the management of segmental and focal vitiligo. DESIGN A simpler and modified method based on that of Olsson and Juhlin was performed. This method uses a shaved biopsy skin sample up to one tenth the size of the recipient area. The skin sample is incubated, and the cells are mechanically sep...

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Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation.

Cytomegalovirus (CMV) infection was detected in 65 of 143 (45%) autologous bone marrow transplant (BMT) patients. CMV pneumonitis occurred in only 2% of the patients and CMV retinitis occurred in none. Infection occurred in half of the 40 initially seronegative patients and 47% of the 94 initially seropositive patients. Among initially seropositive patients, platelet recovery was slower in infe...

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Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo*

BACKGROUND Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. OBJECTIVES To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. METHODS Case series stud...

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Allogeneic Bone Marrow Transplantation

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...

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ژورنال

عنوان ژورنال: Indian Journal of Dermatology

سال: 2015

ISSN: 0019-5154

DOI: 10.4103/0019-5154.164364