Subversion of Innate Immune Signaling Through Molecular Mimicry
نویسندگان
چکیده
منابع مشابه
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL.
Gram-negative bacteria belonging to the Brucella species cause chronic infections that can result in undulant fever, arthritis, and osteomyelitis in humans. Remarkably, Brucella sp. genomes encode a protein, named TcpB, that bears significant homology with mammalian Toll/IL-1 receptor domains and whose expression causes degradation of the phosphorylated, signal competent form of the adapter MyD...
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ژورنال
عنوان ژورنال: Journal of Clinical Immunology
سال: 2010
ISSN: 0271-9142,1573-2592
DOI: 10.1007/s10875-010-9435-0