Substrate Specificity of Hexokinases

Substrate Specificity of MMPs

The substrate specificity of fumarase.

The substrate specificity of fumarase has been studied by measuring the ability of the enzyme to hydrate or dehydrate derivatives of fumarate and L-malate. Fumarase was observed to hydrate fumarate and its derivatives in the order, fluorofumarate > fumarate > chlorofumarate > bromofumarate > acetylenedicarboxylate > iodofumarate > mesaconate. With the exception of fluorofumarate, water was adde...

2 Substrate Specificity of MMPs

Hexokinases and cardioprotection.

As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of the mitochondrial permeability transition p...

Substrate specificity of soybean lipoxidase.

Purified soybean lipoxidase was used to test the substrate specificity of all cis,ck-methylene-interrupted isomers of linoleic acid. The natural 9, U-isomer was found to be the best substrate, and the 13,16-isomer 50% as effective. The presence of calcium ions broadened the pattern of specificity. The rates of reaction of a series of polyunsaturated acids in which chain length, number of double...