Substrate recognition by nonribosomal peptide synthetase multi-enzymes
نویسندگان
چکیده
منابع مشابه
Substrate recognition by nonribosomal peptide synthetase multi-enzymes.
Nonribosomal peptide synthetases (NRPSs) are giant multi-domain enzymes that catalyse the biosynthesis of many commercially important peptides produced by bacteria and fungi. Several studies over the last decade have shown that many of the individual domains within NRPSs exhibit significant substrate selectivity, which impacts on our ability to engineer NRPSs to produce new bioactive microbial ...
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We previously reported that a series of gangliosides inhibited the activity of an enzyme NAD glycohydrolase (CD38), and that those with tandem sialic acid residues in the sugar chain had great inhibitory effect. We describe the results of computer simulations on threedimensional and electronic structures of gangliosides to clarify the causative factors of difference in the inhibitory effect and...
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ژورنال
عنوان ژورنال: Microbiology
سال: 2004
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.26837-0