Substrate-induced Conformational Changes in Human UMP/CMP Kinase
نویسندگان
چکیده
منابع مشابه
Crystal structures of human SIRT3 displaying substrate-induced conformational changes.
SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases. We report the first sets of crystal structures of human SIRT3, ...
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In eqn [1], E is the stable formof the enzyme in the free state and Eact is the conformation of the enzyme stabilized by interaction with the substrate S; P represents the reaction product. The structure Eact is more complementary to the substrate than is E and thus is the more catalytically active form.Changes in the conformationof an enzymeas a result of substrate binding might be anticipated...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m401989200