منابع مشابه
Substance P and Acute Pain in Patients Undergoing Orthopedic Surgery
OBJECTIVE There is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain. The goal of the research was to find the correlation between SP level changes and acute pain intensity in patients with rheumatoid ...
متن کاملSubstance p and pain in orthodontics: A brief review
These neurotransmitters are capable to act on specific receptors expressed in nociceptive sensory neuron thus resulting in the production of second messengers and eventually activating the downstream pathway of protein kinase and phospholipases . Peripheral nociceptors are detectors of specific biochemical compounds and are also constituted by ion channels. Both type of receptors are involved i...
متن کاملPeripheral Mechanisms of Dental Pain: The Role of Substance P
Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimuli and inflammatory processes. The major role of substance P in the onset of dental pain and infla...
متن کاملSubstance P in ovarian carcinoid.
A high content of substance P (124 ng/g wet tissue) was demonstrated by radioimmunoassay in lymph node metastases in a patient with bilateral ovarian carcinoid tumours. The plasma substance P level was elevated but urinary 5-hydroxyindoleacetic acid (5-HIAA) was low. It is suggested that, in some carcinoid patients, an elevated plasma substance P level may help diagnosis and follow-up when urin...
متن کاملImmunomodulatory Properties of Substance P
Communication between nerves and immune and inflammatory cells of the small and large intestine plays a major role in the modulation of several intestinal functions, including intestinal motility, ion transport, and mucosal permeability. Neuroimmune interactions at intestinal sites have been associated with the pathophysiology of infectious and enterotoxin-mediated diarrhea and intestinal infla...
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/32776