Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms
نویسندگان
چکیده
منابع مشابه
Germinal Center Active B Cell Receptor Signaling in the Cutting Edge: An In Vivo Reporter Reveals
Long-lasting Ab responses rely on the germinal center (GC), where B cells bearing high-affinity Ag receptors are selected from a randomly mutated pool to populate the memory and plasma cell compartments. Signaling downstream of the BCR is dampened in GC B cells, raising the possibility that Ag presentation and competition for T cell help, rather than Ag-dependent signal-ing per se, drive these ...
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Follicular dendritic cells (FDCs) and complement receptor (Cr)1 and complement receptor (Cr)2 are important for the generation of humoral immunity. Cr1/2 expression on B cells and FDCs was shown to provide a secondary signal for B cell activation, to facilitate transport of Ag in immune follicles, and to enhance retention of immune complexes by FDCs. We show in this study that murine B cells pr...
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Germinal centers (GC) are the main sites where antigen-activated B-cell clones expand and undergo immunoglobulin gene hypermutation and selection. Iterations of this process will lead to affinity maturation, replicating Darwinian evolution on the cellular level. GC B-cell selection can lead to four different outcomes: further expansion and evolution, apoptosis (non-selection), or output from th...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2014
ISSN: 0014-2980
DOI: 10.1002/eji.201444538