Subnormothermic Oxygenated Perfusion Optimally Preserves Donor Kidneys Ex Vivo

Abstract: Ex-vivo Subnormothermic Oxygenated Machine Perfusion of Swine Forelimbs Enables Prolonged Graft Preservation Prior to Transplantation

RESULTS: Two recipients were euthanized within 2 weeks of DBMT due to neutropenic sepsis and posttransplant lymphoproliferative disorder but both VCAs remained viable up to experimental endpoint. M4515 (full MHC-mismatched recipient) has been off of all immunosuppression for 3 weeks without any evidence of rejection. M3815 (haplomatched) developed mixed chimerism transiently at 6 weeks after DB...

Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion

We report the successful transplantation of a pair of human kidneys that were declined for transplantation due to inadequate in situ perfusion but subsequently transplanted after perfusion and assessment using ex vivo normothermic perfusion (EVNP). The kidneys were from a 35-year-old man, a donation after circulatory death donor. Both kidneys were declined by all UK transplant centers. On arriv...

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

The success of liver transplantation has resulted in a dramatic organ shortage. In most transplant regions 20-30% of patients on the waiting list for liver transplantation die without receiving an organ transplant or are delisted for disease progression. One strategy to increase the donor pool is the utilization of marginal grafts, such as fatty livers, grafts from older donors, or donation aft...

Ex Vivo Anti-CD3 Antibody-Activated Donor

Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants.

BACKGROUND A significant proportion of kidneys procured for transplantation are discarded because of concerns about their suitability. In this study ex vivo normothermic perfusion (EVNP) was used as a quality assessment device before renal transplantation. METHODS Seventy-four human kidneys deemed unsuitable for transplantation following retrieval underwent 60 min of EVNP with an oxygenated r...