Sublingual Buprenorphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Trial
نویسندگان
چکیده
منابع مشابه
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
AIMS More than half of infants exposed to opioids in utero develop neonatal abstinence syndrome (NAS) of severity to require pharmacological therapy. Current treatments are associated with prolonged hospitalization. We sought to optimize the dose of sublingual buprenorphine in the treatment of NAS. DESIGN Randomized, Phase 1, open-label, active-control clinical trial comparing sublingual bupr...
متن کاملBuprenorphine for the Treatment of the Neonatal Abstinence Syndrome.
BACKGROUND Current pharmacologic treatment of the neonatal abstinence syndrome with morphine is associated with a lengthy duration of therapy and hospitalization. Buprenorphine may be more effective than morphine for this indication. METHODS In this single-site, double-blind, double-dummy clinical trial, we randomly assigned 63 term infants (≥37 weeks of gestation) who had been exposed to opi...
متن کاملLaser Acupuncture for Neonatal Abstinence Syndrome: A Randomized Controlled Trial.
BACKGROUND Neonatal abstinence syndrome (NAS) is usually treated with opiate derivatives and supported with nonpharmacological treatment. METHODS This prospective, randomized, controlled, blinded, single-center study was carried out between March 2009 and November 2014. Newborn infants diagnosed with NAS after maternal opioid substitution therapy were eligible for inclusion. Infants were rand...
متن کاملTreatment of neonatal abstinence syndrome.
Neonatal abstinence syndrome (NAS) is suffered by infants withdrawing from substances on which they have become physically dependent after in utero exposure. They may require prolonged treatment and spend weeks or even months in hospital. A wide range of drugs have been used to treat NAS. The efficacy of few, however, have been adequately investigated. Evidence suggests that opioids are the mos...
متن کاملNeonatal abstinence syndrome after methadone or buprenorphine exposure.
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However, prenatal exposure to methadone is associated with a neonatal abstinence syndrome (NAS) characterized by central nervous system hyperirritability and autonomic nervous system dysfunction, which often requires medication and extended hospitalization. Buprenorphine, a parti...
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ژورنال
عنوان ژورنال: PEDIATRICS
سال: 2008
ISSN: 0031-4005,1098-4275
DOI: 10.1542/peds.2008-0571