Subjective effects of tizanidine (DS103-282), a centrally acting muscle relaxant in healthy volunteers. Double blind comparative study vs. diazepam and placebo.
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منابع مشابه
Efficacy of Tinospora cordifolia on Learning and Memory in Healthy Volunteers: A Double-Blind, Randomized, Placebo Controlled Study
Background. Tinospora cordifolia, an Indian medicinal plant, has been reported to have beneficial effects on disorders like peptic ulcer, hepatobiliary disorders, rheumatism, infectious diseases etc. It enhances cognition in normal rats and successfully overcomes cyclosporine induced memory deficit. Methods. Thirty healthy volunteers of age 18-30 years received Tinospora cordifolia (500 mg of p...
متن کاملEffect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems.
Experiments were performed on intact and spinalized rats anesthetized with urethane and alpha-chloralose. In intact rats, administration of tizanidine (0.1 mg/kg, i.v.) decreased the mono- (MSR) and polysynaptic reflex potentials (PSR). Blood pressure was initially elevated and then lowered by tizanidine. Although pretreatments with hexamethonium and phentolamine prevented the tizanidine-induce...
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STUDY OBJECTIVES Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant. This study aims at objectively investigating the effects of single-dose mirtazapine on sleep of healthy volunteers. DESIGN AND SETTING We studied the effect of acute administration of mirtazapine (30 mg) on the sleep polysomnogram, using a double-blind, placebo-controlled design. Subjects s...
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متن کاملCentral muscle relaxant effects of diazepam.
Motor depressant effects of diazepam were studied in the intact, decerebrate and high spinal cat. Diazepam (0.125516 mg/kg, i.v.) produced a depression of both the patellar and linguomandibular reflexes in the intact cat. In the high spinal (Cl) cat only the linguomandibular reflex was depressed. Facilitation and inhibition of the patellar reflex elicited in both intact and high spinal (Cl) cat...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1986
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.17.509