Subgroup identification in dose-finding trials via model-based recursive partitioning
نویسندگان
چکیده
منابع مشابه
Subgroup Analysis via Recursive Partitioning
Subgroup analysis is an integral part of comparative analysis where assessing the treatment effect on a response is of central interest. Its goal is to determine the heterogeneity of the treatment effect across subpopulations. In this paper, we adapt the idea of recursive partitioning and introduce an interaction tree (IT) procedure to conduct subgroup analysis. The IT procedure automatically f...
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Identification of subgroups of patients for which treatment A is more effective than treatment B, and vice versa, is of key importance to the development of personalized medicine. Several tree-based algorithms have been developed for the detection of such treatment-subgroup interactions. In many instances, however, datasets may have a clustered structure, where observations are clustered within...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2018
ISSN: 0277-6715
DOI: 10.1002/sim.7594