Subclinical atherosclerosis of the carotid arteries in patients with rheumatoid arthritis with low cardiovascular risk

Aim. To evaluate the detection rate of subclinical carotid atherosclerosis in rheumatoid arthritis (RA) patients with low cardiovascular risk (CVR).
 Materials and methods. The study included 182 RA CVR (mSCORE1%) no established diseases a control group comprising 100 people. Atherosclerotic lesion arteries was assessed using Doppler ultrasound determined by atherosclerotic plaque (ASP) local increase thickness intima-media complex (IMT) 1.5 mm.
 Results. Carotid ASP were observed more frequently than (17% versus 8%; p=0.02). frequency did not depend on stage or activity ongoing therapy. In RA, associated traditional factors: detected 4 times often men women (48% 12%, p0.01); IMT correlated age (R=0.46), body mass index (R=0.17), LDL-C level (R=0.20), systolic blood pressure (R=0.17); p0.05 all cases. According to multivariate model, developing increased presence dyslipidemia (odds ratio OR 2.97; 95% confidence interval CI 1.366.49; p=0.006) arterial hypertension (OR 2.16; 1.034.54; p=0.04). ASP, sCD40L (R=0.32; p=0.04) cholesterol concentration (R=0.39; p=0.01).
 Conclusion. Subclinical lesions 24% almost 2 group. CVR, 23 concomitant dyslipidemia. factors age, gender, lipid levels indicators, cases an immunoinflammatory marker sCD40L.