Subcellular localization as a limiting factor for utilization of decoy oligonucleotides

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Subcellular localization as a limiting factor for utilization of decoy oligonucleotides.

Transfection of cells with short double-stranded synthetic DNA molecules that contain a transcription factor binding site, known as decoy oligodeoxynucleotides (ODNs), has been proposed as a novel approach in vitro and in vivo for the study of gene regulation and for gene therapy. Once delivered into cells, decoy ODNs are predicted to bind to nuclear transcription factors, preventing their bind...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2004

ISSN: 1362-4962

DOI: 10.1093/nar/gnh139