STUDY OF VITAMIN D3-FORTIFIED GOAT KEFIR ON PLASMA FIBRINOGEN LEVELS OF DIABETIC RATTUS NORVEGICUS RATS

ABSTRACTBackground: Diabetes mellitus is often associated with the occurrence of complications. Haemostatic factors, especially hyperfibrinogenaemia, a common cause complication. Goat kefir and vitamin D3 may act as an antioxidant anti-inflammation agent which can repair pancreatic beta cells.Objectives: This study aimed to analyse effect D3-fortified goat milk plasma fibrinogen levels in diabetic rats. Materials Methods: was experimental pre-post only group design. The samples were 21 male rats divided into four groups; negative control (K-), positive (K +), treated unfortified (P1), (P2). 35-day intervention conducted, dose 2 ml/200 g BW/day D 600 IU. Fasting blood glucose assessed pre- post-intervention. Blood level evaluated by GOD-PAP method, while Enzyme-Linked Immunosorbent Assay (ELISA) method. data analysed paired t-test One-Way ANOVA. Results: There not significant difference between groups. groups both showed insignificant decrease fibrinogen. went down 13.47 mg/dl from 16.49 (p = 0.49). Meanwhile, 26.81 24.94 (p=0.83). On other hand, there fasting 181.75 116.25 (p=0.03).Conclusion Our results demonstrate that administration but Keywords : Mellitus; Fastin glucose; Fibrinogen; kefir; Vitamin Fortification