Study of specific nanoenvironments containing α-helices in all-α and (α+β)+(α/β) proteins
نویسندگان
چکیده
منابع مشابه
Stable Single α-Helices Are Constant Force Springs in Proteins*
Single α-helix (SAH) domains are rich in charged residues (Arg, Lys, and Glu) and stable in solution over a wide range of pH and salt concentrations. They are found in many different proteins where they bridge two functional domains. To test the idea that their high stability might enable these proteins to resist unfolding along their length, the properties and unfolding behavior of the predict...
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Using a new representation for interactions in protein sequences based on correlations between pairs of amino acids, we have examined α-helical segments from known protein structures for important interactions. Traditional techniques for representing protein sequences usually make an explicit assumption of conditional independence of residues in the sequences. Protein structure analyses, howeve...
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Molecular dynamics (MD) is a valuable tool for the investigation of functional elements in biomolecules, providing information on dynamic properties and processes. Previous work by our group has characterized static geometric properties of the two MHC α-helices comprising the peptide binding region recognized by T cells. We build upon this work and used several spline models to approximate the ...
متن کاملTOPTMH: Topology Predictor for Transmembrane α-Helices
Alpha-helical transmembrane proteins mediate many key biological processes and represent 20–30% of all genes in many organisms. Due to the difficulties in experimentally determining their high-resolution 3D structure, computational methods that predict their topology (transmembrane helical segments and their orientation) are essential in advancing the understanding of membrane proteins’ structu...
متن کاملCorrection: Distribution and evolution of stable single α-helices (SAH domains) in myosin motor proteins
[This corrects the article DOI: 10.1371/journal.pone.0174639.].
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0200018