Study of HER2 in Breast Cancer Disease

Human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase protein, Positive HER2 status has been linked with aggressive tumor behavior and resistance to cytotoxic endocrine therapies. Breast cancer complex disease the major cause of mortality in women worldwide. There are several subtypes breast many options for treatment. This study aimed know hormonal changes associated HER2+ve pre postmenopausal Iraqi women. included 80 healthy 78 newly diagnosed patients, 35 43 premenopausal. Depending on test patients were divided into two groups, positive negative. The group was adopted negative excluded. Our result shows that there significant decrease progesterone non-significant increase Estradiol, FSH, LH premenopausal but estradiol, +ve patients. TSH within normal range both compared control group. relationship between progesterone, test. Also, TSH, FSH. And