Study of clinical and biochemical profile of neonatal seizures

Introduction: Neonatal Seizure is defined as a paroxysmal involuntary disturbance of cerebral function. seizures are common problem. Common etiology neonatal brain disorders, hypoxic-ischemic encephalopathy, central nervous system (CNS) infections, CNS bleeds, and structural anomalies the or secondary to metabolic problems, for example, hypoglycemia, hyponatremia, other electrolyte disturbances.Objective: To study Clinical Biochemical abnormalities associated with seizures.Material Methods: An observational was conducted in ninety newborns admitted intensive care unit (NICU). After taking complete history appropriate physical examination, blood sample collected detecting before instituting specific therapy.Results: Total neonates presented were enrolled this study. Among them, male 52 (57.78%), female 38 (42.22%). In present study, majority 30% had onset within 24 hr. neonates, number subtle 62 (68.89%), tonic seizure 11 (12.22%), clonic 10 (11.11%).In hypoglycemia reported 32.22% followed by birth asphyxia 25.56%, hypocalcemia 24.44% hyponatremia 13.33% hypomagnesemia 4.44% neonates.Conclusion: Early identification management biochemical essential satisfactory long-term outcome. The causes India include hypocalcemia, asphyxia, hypomagnesemia.